Prevalence and global distribution of blaKPC-2 and blaNDM-1 genes in Klebsiella Pneumoniae

Author:

Zhang Xiufeng,Li Fangping,Cui Shiyun,Mao Lisha,Li Xiaohua,Furqan Awan,Lv Weibiao,Zeng Zhenling

Abstract

AbstractCarbapene-resistant Klebsiella pneumoniae infections have caused a major concern and posed a global health threat to public. blaKPC-2 and blaNDM-1 genes are the most widely reported of carbapenem resistance genes in K. pneumoniae. In this study, we investigated phylogenetic relationships of carbapene-resistant K. pneumoniae from a tertiary hospital between 2013 and 2018 in China and analyzed the global epidemiology and distribution of blaKPC-2 and blaNDM-1 gene in K. pneumoniae based on 1579 NGS genomes. We found that 19 carbapene-resistant K. pneumoniae isolated were divided into five lineages and all had high genotypic and phenotypic resistance. Two lineages (mostly ST11 and ST25) were the major type detected carrying blaKPC-2 and blaNDM-1 gene, respectively. Among global genomes data, 147 known ST types have been identified and ST11 and ST258 were the globally prevalent clones. Genetic environment analysis showed that the ISKpn27-blaKPC-2-ISKpn6 and blaNDM-1-ble-trpf-nagA may be the core structure in the horizontal transfer of blaKPC-2 and blaNDM-1, respectively. In addition, DNA transferase (hin) may be involved in the horizontal transfer or the expression of blaNDM-1. This study sheds some light on the genetic environment of blaKPC-2 and blaNDM-1 and should foster further studies about the mechanism of carbapene-resistant K. pneumoniae dissemination.

Publisher

Cold Spring Harbor Laboratory

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3