Abstract
AbstractGnathostome jaw patterning involves focal instructive signals from the embryonic surface cephalic ectoderm (SCE) to a fungible population of cranial neural crest. The spatial refinement of these signals, particularly for those patterning the upper jaws, is not fully understood. We demonstrate thatFoxg1, broadly expressed in the SCE overlying the upper jaw primordia, is required for both neurocranial and viscerocranial development, including the sensory capsules, neurocranial base, middle ear, and upper jaws.Foxg1controls upper jaw molecular identity and morphologic development by actively inhibiting the inappropriate acquisition of lower jaw molecular identity within the upper jaw primordia, and is necessary for the appropriate elaboration of the λ-junction, choanae, palate, vibrissae, rhinarium, upper lip and auxiliary eye. It regulates intra-epithelial cellular organization, gene expression, and the topography of apoptosis within the SCE.Foxg1integrates forebrain and skull development and genetically interacts withDlx5to establish a single, rostral cranial midline.
Publisher
Cold Spring Harbor Laboratory
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