Author:
Xiao Fei,Tang Meiwen,Zheng Xiaobin,Li Chunna,He Jianzhong,Hong Zhongsi,Huang Siwen,Zhang Zhenyi,Lin Xianqi,Fang Zhaoxiong,Lai Renxu,Chen Shoudeng,Liu Jing,Huang Jin,Xia Jinyu,Li Zhonghe,Jiang Guanmin,Liu Ye,Li Xiaofeng,Shan Hong
Abstract
AbstractThe new coronavirus (SARS-CoV-2) outbreak originating from Wuhan, China, poses a threat to global health. While it’s evident that the virus invades respiratory tract and transmits from human to human through airway, other viral tropisms and transmission routes remain unknown. We tested viral RNA in stool from 73 SARS-CoV-2-infected hospitalized patients using rRT-PCR. 53.42% of the patients tested positive in stool. 23.29% of the patients remained positive in feces even after the viral RNA decreased to undetectable level in respiratory tract. The viral RNA was also detected in gastrointestinal tissues. Furthermore, gastric, duodenal and rectal epithelia showed positive immunofluorescent staining of viral host receptor ACE2 and viral nucleocapsid protein in a case of SARS-CoV-2 infection. Our results provide evidence for gastrointestinal infection of SARS-CoV-2, highlighting its potential fecal-oral transmission route.
Publisher
Cold Spring Harbor Laboratory
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