Basis of executive functions in fine-grained architecture of cortical and subcortical human brain networks

Author:

Assem MoatazORCID,Shashidhara Sneha,Glasser Matthew F.,Duncan John

Abstract

AbstractTheoretical models suggest executive functions are supported by both domain-general and domain-specific processes. While some brain imaging studies claim executive tasks recruit a domain-general multiple-demand (MD) brain system, many studies argue the spatially coarse results of traditional imaging methods have blurred fine-grained functionally fractionated domain-specific systems into one. To address this challenge, we scanned participants using the high spatial resolution multimodal MRI approach of the Human Connectome Project while they performed tasks targeting executive demands of updating, shifting and inhibition. The results show that different executive activations overlap, at the single subject level, within MD regions. Critically, each task’s topography shifts within MD regions to form a unique intersection with adjacent fine-grained resting-state networks. In this intersection, the strongest activations arise at neurobiologically defined network borders. Outside cerebral cortex, matching results are seen in circumscribed regions of the caudate nucleus, thalamus and cerebellum. Using precise imaging methods, these results suggest a novel framework whereby partially-specialised networks recruit neighbouring MD areas to generate distinct executive functions.

Publisher

Cold Spring Harbor Laboratory

Cited by 3 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3