Association Between Nonalcoholic Fatty Pancreatic Disease and Triglyceride/Glucose Index

Abstract

AbstractNonalcoholic fatty pancreatic disease (NAFPD) is an increase of fat in the pancreas, and has an important association with insulin resistance (IR) and type 2 diabetes mellitus. Research has confirmed that the triglyceridemia/glycemia (TyG) index determines IR as much as does the hyperinsulinemic-euglycemic clamp assessment as the homeostasis model testing of IR (HOMA-IR).ObjectiveTo evaluate the association between degree of NAFPD and TyG index.MethodsIn 72 patients undergoing ultrasound of abdomen with a diagnosis of NAFPD, insulin, glucose, and triglycerides levels were evaluated. The HOMA-IR index was used as a reference of IR. The degrees of NAFPD and the TyG index were presented through the receiver operating characteristics (ROC) curves in order to evaluate the association between different degrees of NAFPD and the TyG index and its correlation with HOMA-IR.ResultsThere was a statistically significant correlation between the degree of NAFPD and the TyG index. The AUROC curve for the TyG index for predicting the degree of NADPD was 0.855 (0.840–0.865). The intensity-adjusted probabilities of the degree of NAFPD were more strongly associated with TyG values when compared with HOMA-IR.ConclusionIn this study the TyG index correlated positively with the degree of NAFPD, performing better than HOMA-IR.