Estimating the epidemic reproduction number from temporally aggregated incidence data: a statistical modelling approach and software tool

Abstract

BackgroundThe time-varying reproduction number (Rt) is an important measure of epidemic transmissibility; it can directly inform policy decisions and the optimisation of control measures. EpiEstim is a widely used software tool that uses case incidence and the serial interval (SI, time between symptoms in a case and their infector) to estimate Rtin real-time. The incidence and the SI distribution must be provided at the same temporal resolution, which limits the applicability of EpiEstim and other similar methods, e.g. for pathogens with a mean SI shorter than the frequency of incidence reporting.MethodsWe use an expectation-maximisation algorithm to reconstruct daily incidence from temporally aggregated data, from which Rtcan then be estimated using EpiEstim. We assess the validity of our method using an extensive simulation study and apply it to COVID-19 and influenza data. The method is implemented in the opensource R package EpiEstim.FindingsFor all datasets, the influence of intra-weekly variability in reported data was mitigated by using aggregated weekly data. Rtestimated on weekly sliding windows using incidence reconstructed from weekly data was strongly correlated with estimates from the original daily data. The simulation study revealed that Rtwas well estimated in all scenarios and regardless of the temporal aggregation of the data. In the presence of weekend effects, Rtestimates from reconstructed data were more successful at recovering the true value of Rtthan those obtained from reported daily data.InterpretationRtcan be successfully recovered from aggregated data, and estimation accuracy can even be improved by smoothing out administrative noise in the reported data.FundingMRC doctoral training partnership, MRC centre for global infectious disease analysis, the NIHR HPRU in Modelling and Health Economics, and the Academy of Medical Sciences Springboard, funded by the AMS, Wellcome Trust, BEIS, the British Heart Foundation and Diabetes UK.