Abstract
AbstractOur recent algorithm,Hapi, infers chromosome-scale haplotypes using genomic data of a small number of single gametes. Its advanced version,IIIandMe, is proposed here to achieve comparable phasing accuracy with as few as three gametes, pushing the analysis to its limit. The new method is validated with simulation and a citrus gamete dataset. The rapid advances in genotyping technologies promise a broad application ofIIIandMein disclosing important genetic information.
Publisher
Cold Spring Harbor Laboratory