Abstract
ABSTRACTHospital-acquired contagions are on the increase and are a substantial cause of clinical and financial burden for healthcare systems. While contagion control plays a major role in curtailing the spread of outbreak organisms, it is not always effective. One organism of particular concern isAcinetobacter baumannii, due to both its persistence in the hospital setting and its ability to acquire antibiotic resistance.A. baumanniihas appeared as a nosocomial pathogen that displays high levels of resistance to antibiotics, and remains resilient against traditional cleaning measures with resistance to Colistin increasingly reported. Given the costs associated and magnitude with hospital acquired infections, and the rise in multidrug-resistant organisms, it is worth re-evaluating our current approaches and observing for substitutes or aides-de-camp to traditional antibiotics therapies. The aims of this study was to determine antimicrobial resistance, antibiofilm patterns and virulence factors ofAcinetobacter baumanniiisolates from hospital system. Among the five drugs used (Amikacin, Gentamicin, Meropenem, Tigecycline and Tazobactam) it was revealing that all the isolates show resistance to all the drugs. It was revealed that 3 isolates show resistance at difference antimicrobial classes in isolate05/JOOTRH/22and17/JOOTRH/22were able to produce all type of the virulence enzymes while isolate11/JOOTRH/22was able to produce all except protease enzyme. The isolates showed that the biofilm formation inhibitory effects of the various concentrations (0.5, 0.25, 0.125, 0.0625 and 0.03125 mg ml−1) were significantly lower than that of the positive control, an indication that biofilm formation was inhibited at these concentrations
Publisher
Cold Spring Harbor Laboratory