Abstract
Work on PARPs—a family of enzymes that catalyze ADP-ribosylation, a posttranslational modification of proteins—has resulted in major advances and reached important milestones. The past decade has seen new discoveries in areas well beyond the historical focus on DNA repair, which are having impacts on the understanding and treatment of human disease. This special focus section of Genes & Development includes seven reviews that highlight these discoveries and point the way forward for future advances in the field.
Funder
National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases
Cancer Prevention and Research Institute of Texas
Cecil H. and Ida Green Center for Reproductive Biology Sciences Endowment
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Cited by
24 articles.
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