The Organization and Rate of Evolution of Wheat Genomes Are Correlated With Recombination Rates Along Chromosome Arms

Author:

Akhunov Eduard D.,Goodyear Andrew W.,Geng Shu,Qi Li-Li,Echalier Benjamin,Gill Bikram S.,Miftahudin ,Gustafson J. Perry,Lazo Gerard,Chao Shiaoman,Anderson Olin D.,Linkiewicz Anna M.,Dubcovsky Jorge,Rota Mauricio La,Sorrells Mark E.,Zhang Deshui,Nguyen Henry T.,Kalavacharla Venugopal,Hossain Khwaja,Kianian Shahryar F.,Peng Junhua,Lapitan Nora L.V.,Gonzalez-Hernandez Jose L.,Anderson James A.,Choi Dong-Woog,Close Timothy J.,Dilbirligi Muharrem,Gill Kulvinder S.,Walker-Simmons M. Kay,Steber Camille,McGuire Patrick E.,Qualset Calvin O.,Dvorak Jan

Abstract

Genes detected by wheat expressed sequence tags (ESTs) were mapped into chromosome bins delineated by breakpoints of 159 overlapping deletions. These data were used to assess the organizational and evolutionary aspects of wheat genomes. Relative gene density and recombination rate increased with the relative distance of a bin from the centromere. Single-gene loci present once in the wheat genomes were found predominantly in the proximal, low-recombination regions, while multigene loci tended to be more frequent in distal, high-recombination regions. One-quarter of all gene motifs within wheat genomes were represented by two or more duplicated loci (paralogous sets). For 40 such sets, ancestral loci and loci derived from them by duplication were identified. Loci derived by duplication were most frequently located in distal, high-recombination chromosome regions whereas ancestral loci were most frequently located proximal to them. It is suggested that recombination has played a central role in the evolution of wheat genome structure and that gradients of recombination rates along chromosome arms promote more rapid rates of genome evolution in distal, high-recombination regions than in proximal, low-recombination regions.

Publisher

Cold Spring Harbor Laboratory

Subject

Genetics (clinical),Genetics

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