Author:
Muniozguren Nerea L.,Zappa Francesca,Acosta-Alvear Diego
Abstract
AbstractThe integrated stress response (ISR) is a fundamental signaling network that reprograms the transcriptome and proteome to leverage the cell’s biosynthetic capacity against different stresses. Signaling plasticity is enabled by distinct ISR sensor kinases that detect specific perturbations. The ISR is dichotomous, with tailored homeostatic outputs and a terminal one engaged upon overwhelming stress. Through a chemical-genetics approach that uncouples natural stress inputs from ISR actuation, we show that the ISR engages an input-agnostic, cell-autonomous apoptosis mechanism that requires unconventional signaling by death receptor 5. Our results indicate that a common ISR mechanism eliminates terminally injured cells.
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
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1. Signaling plasticity in the integrated stress response;Frontiers in Cell and Developmental Biology;2023-12-07