Volume growth in animal cells is cell cycle dependent and shows additive fluctuations

Author:

Cadart ClotildeORCID,Piel MatthieuORCID,Lagomarsino Marco CosentinoORCID

Abstract

AbstractThe way proliferating animal cells coordinate the growth of their mass, volume, and other relevant size parameters is a long-standing question in biology. Studies focusing on cell mass have identified patterns of mass growth as a function of time and cell cycle phase, but little is known about volume growth. To address this question, we improved our fluorescence exclusion method of volume measurement (FXm) and obtained 1700 single-cell volume growth trajectories of HeLa cells. We find that, during most of the cell cycle, volume growth is close to exponential and proceeds at a higher rate in S-G2 than in G1. Comparing the data with a mathematical model, we establish that the cell-to-cell variability in volume growth arises from constant-amplitude fluctuations in volume steps, rather than fluctuations of the underlying specific growth rate. We hypothesize that such “additive noise” could emerge from the processes that regulate volume adaptation to biophysical cues, such as tension or osmotic pressure.

Publisher

Cold Spring Harbor Laboratory

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Eukaryotic Cell Size Control and Its Relation to Biosynthesis and Senescence;Annual Review of Cell and Developmental Biology;2022-10-06

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