Modelling the effect of an improved trace and isolate system in the wake of a highly transmissible Covid-19 variant with potential vaccine escape

Author:

Bowie CamORCID

Abstract

AbstractObjectiveHow helpful would a properly functioning find, test, trace, isolate and support (FTTIS) system be now in the UK with new Covid-19 infections at a low level and half the adult population immunised but with a highly transmissible variant becoming predominant?Designa dynamic causal model of Covid-19 supplied with the latest available empirical data is used to assess the impact of a new highly transmissible variant.Settingthe United Kingdom.Participantsa population based study.Interventionsscenarios are used to explore a Covid-19 transmission rate 50% more and twice the current rate with or without a more effective FTTIS system.Main outcome measuresincidence, death rate and reproductive ratioResultsa small short third wave of infections occurs which does not occur if FTTIS effectiveness is improved from 25% to 30%.Conclusiona modest improvement in FTTIS would prevent a third wave caused by a highly transmissible virus.

Publisher

Cold Spring Harbor Laboratory

Reference11 articles.

1. Parliam entary Public Accounts Select Committee. “Unimaginable” cost of Test & Trace failed to deliver central promise of averting another lockdown - Committees - UK Parliament [Internet]. 2021 [cited 2021 May 24]. Available from: https://committees.parliament.uk/committee/127/public-accounts-committee/news/150988/unimaginable-cost-of-test-trace-failed-to-deliver-central-promise-of-averting-another-lockdown/

2. Exit strategy to control covid-19 and relaunch the economy

3. Cam Bowie . Eating humble pie over Covid 19 control failures - Briefings For Britain [Internet]. 2020 [cited 2021 May 24]. Available from: https://briefingsforbritain.co.uk/eating-humble-pie-over-covid-19-control-failures/

4. Friston. Dynamic causal modelling of COVID-19 | Wellcome Open Research [Internet]. [cited 2021 Apr 12]. Available from: https://wellcomeopenresearch.org/articles/5-89

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