Time Machine: Can a Dye from 1928 be Re-Purposed for Modern, Fluorescence-Based Detection of Amyloid-Like Fibrils?

Abstract

AbstractThis manuscript describes the chemical synthesis of a compound similar to fluorene and Congo red, including characterization of its spectral properties. It was shown that the dye, during interaction with amyloid-like fibrils of several proteins (lysozyme, insulin, and beta-2-microglobulin), has the ability to change fluorescent spectrum. In contrast, monomeric forms of these proteins did not induce significant spectral changes.