Abstract
AbstractThe etiology of anorexia nervosa (AN) remains elusive. Here, we characterize spatially distributed expression patterns of risk genes for AN in the human brain, developing whole-brain maps of AN gene expression. We found that genes associated with AN are most expressed in the brain, relative to all other body tissue types, and demonstrate gene-specific expression patterns which extend to cerebellar, limbic and basal ganglia structures in particular. fMRI meta-analyses reveal that AN gene expression maps correspond with functional brain activity involved in processing and anticipating appetitive and aversive cues.
Publisher
Cold Spring Harbor Laboratory