Visual-motor integration deficits in 3q29 deletion syndrome

Author:

Pollak Rebecca M,Burrell T Lindsey,Cubells Joseph F,Klaiman Cheryl,Murphy Melissa M,Saulnier Celine A,Walker Elaine F,White Stormi Pulver,Mulle Jennifer G

Abstract

AbstractPurpose3q29 deletion syndrome (3q29del) is associated with neuropsychiatric and neurodevelopmental phenotypes. We previously reported that graphomotor weakness is present in up to 78% of individuals with 3q29del. We have now explored nuances of the graphomotor phenotype and its association with other comorbidities in this population.MethodsParticipants were recruited from the online 3q29 registry (3q29deletion.org) for two days of deep phenotyping. 32 individuals with 3q29del (62.5% male) were evaluated with the Beery-Buktenica Developmental Test of Visual-Motor Integration (VMI) to assess visual-motor integration. Participants were also evaluated with measures of cognitive ability, executive function, adaptive behavior, and school function.ResultsMales with 3q29del performed significantly worse than females on the VMI and Motor Coordination subtest. VMI performance was significantly associated with ADHD diagnosis and cognitive ability. Compared to published data from individuals with 22q11.2 deletion syndrome, individuals with 3q29del showed significantly more impairment.ConclusionThe 3q29 deletion is associated with substantial deficits in visual-motor integration, Visual Perception, and Motor Coordination. Our data suggests that 3q29del may qualify as a nonverbal learning disability, and that all individuals with 3q29del may benefit from early interventions, including occupational therapy.

Publisher

Cold Spring Harbor Laboratory

Reference78 articles.

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Adaptive behaviour deficits in individuals with 3q29 deletion syndrome;Journal of Intellectual Disability Research;2023-09-22

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