Abstract
AbstractIncreasing fungicide dose tends to lead to better short-term control of plant diseases. However, high doses select more rapidly for fungicide resistant strains, reducing long-term disease control. When resistance is qualitative and complete – i.e. resistant strains are unaffected by the chemical and resistance requires only a single genetic change – using the lowest possible dose ensuring sufficient control is well-known as the optimal resistance management strategy. However, partial resistance (where resistant strains are still partially suppressed by the fungicide) and quantitative resistance (where a range of resistant strains are present) remain ill-understood. Here we use a model of quantitative fungicide resistance (parameterised for the economically-important fungal pathogen Zymoseptoria tritici) which handles qualitative partial resistance as a special case. We show that – for both qualitative partial resistance and quantitative resistance – although low doses are optimal for resistance management, for some model parameterisations the benefit does not outweigh the improvement in control from increasing doses. Via a machine learning approach (a gradient-boosted trees model combined with Shapley values to facilitate interpretability) we interpret the effect of parameters controlling pathogen mutation and characterising the fungicide, in addition to the timescale of interest.
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
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