Abstract
AbstractCrossover rate is mostly studied with domesticated or lab-reared populations and little is known about its genetic variation in the wild. We studied the variation and genetic underpinnings of crossover rate in outbred wild nine- (Pungitius pungitius) and three-spined (Gasterosteus aculeatus) sticklebacks. In both species, the crossover rate of females exceeded that of males as did also its repeatability (RFemales =0.21–0.33, RMales=0.026–0.11), implying individual differences of crossover rate in females, but no or less so in males. However, in both species and sexes additive genetic variance and heritability of crossover rate were effectively zero. A review of the previously reported repeatability and heritability estimates revealed that the repeatabilities in stickleback females were moderately high, whereas those in males were very low. Genome-wide association analyses recovered a few candidate regions possibly involved with control of crossover rate. The low additive genetic variance of crossover rate in wild sticklebacks suggest limited evolvability of crossover rate.
Publisher
Cold Spring Harbor Laboratory
Reference72 articles.
1. Fitting Linear Mixed-Effects Models Using lme4;Journal of Statistical Software,2015
2. PRDM9 Is a Major Determinant of Meiotic Recombination Hotspots in Humans and Mice
3. Bell. M. A. , & Foster, S. A. (1994) Introduction to the evolutionary biology of the threespine stickleback. In The Evolutionary Biology of the Threespine Stickleback, ed. MA Bell , SA Foster Oxford, UK: Oxford Univ. Press
4. Rapid and Accurate Haplotype Phasing and Missing-Data Inference for Whole-Genome Association Studies By Use of Localized Haplotype Clustering
5. Genotype Imputation with Millions of Reference Samples