Author:
Kendall Ellen K.,Olaker Veronica R.,Kaelber David C.,Xu Rong,Davis Pamela B.
Abstract
AbstractRecently, the Centers for Diseases and Control released a nationwide health alert about an increase in hepatitis cases of unknown origin in children, raising concern about potential sequelae of COVID-19 infection. In this study, we test whether there was increased risk of elevated serum liver enzymes and bilirubin following COVID-19 infection in children. We performed a retrospective cohort study on a nation-wide database of patient electronic health records (EHRs) in the US. The study population comprise 796,369 children between the ages of 1-10 years including 245,675 who had contracted COVID-19 during March 11, 2020 - March 11, 2022 and 550,694 who contracted non-COVID other respiratory infection (ORI) during the same timeframe.Compared to children infected with other respiratory infections, children infected with COVID-19 infection were at significantly increased risk for elevated AST or ALT (hazard ratio or HR: 2.52, 95% confidence interval or CI: 2.03-3.12) and total bilirubin (HR: 3.35, 95% CI: 2.16-5.18). These results suggest acute and long-term hepatic sequelae of COVID-19 in pediatric patients. Further investigation is needed to clarify if post-COVID-19 related hepatic injury described in this study is related to the current increase in pediatric hepatitis cases of unknown origin.
Publisher
Cold Spring Harbor Laboratory
Reference6 articles.
1. COVID-19 and liver disease: mechanistic and clinical perspectives
2. Molecular consequences of SARS-CoV-2 liver tropism
3. Rawat, S. K. , Asati, A. A. , Jain, A. , Mishra, N. , & Ratho, R. K. (2021). Covid-19 associated hepatitis in children (CAH-C) during the second wave of SARS-COV-2 infections in central India: Is it a complication or transient phenomenon. https://doi.org/10.1101/2021.07.23.21260716
4. CDC alerts providers to hepatitis cases of unknown origin. Centers for Disease Control and Prevention. https://www.cdc.gov/media/releases/2022/s0421-hepatitis-alert.html. Published April 21, 2022. Accessed May 5, 2022.
5. TriNetX. Home page. Accessed April 28. 2022. https://trinetx.com/
Cited by
5 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献