Computerized biofeedback to characterize Pupil Cycle Time (PCT) in neuropathies and retinopathies

Abstract

AbstractPupillary responses to light offer a convenient and objective way to quickly assess the functional health of the anterior afferent visual pathways. We here present the characteristics of Pupil Cycle Time (PCT) obtained with a computerized biofeedback setting in patients with retinal and optic nerve diseases. The spectral analysis of the sustained pupillary oscillations elicited over 45 seconds of passive fixation of colored displays with different spatial configurations provides relevant information that allow distinguishing patients from healthy participants with good sensitivity and specificity. PCT measures done with this method could complement the current functional examination of chronic ophthalmic diseases whose prevalence worryingly increases worldwide.