Abstract
AbstractPredicting the cellular activities of proteins from their primary amino acid sequences is a highly desirable capability that could greatly enhance our functional understanding of the proteome. Here, we demonstrate CELL-E, a text-to-image transformer architecture, which given a protein sequence and a reference image for cell (or nucleus) morphology, can generate a 2D probability density map of the protein distribution within cells. Unlike previousin silicomethods, which rely on existing, discrete class annotation of protein localization to predefined subcellular compartments, CELL-E uses imaging data directly, thus relying on a native description of protein localization relative to the cellular context.
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
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