ArcticAI: A Deep Learning Platform for Rapid and Accurate Histological Assessment of Intraoperative Tumor Margins

Abstract

AbstractSuccessful treatment of solid cancers relies on complete surgical excision of the tumor either for definitive treatment or before adjuvant therapy. Radial sectioning of the resected tumor and surrounding tissue is the most common form of intra-operative and post-operative margin assessment. However, this technique samples only a tiny fraction of the available tissue and therefore may result in incomplete excision of the tumor, increasing the risk of recurrence and distant metastasis and decreasing survival. Repeat procedures, chemotherapy, and other resulting treatments pose significant morbidity, mortality, and fiscal costs for our healthcare system. Mohs Micrographic Surgery (MMS) is used for the removal of basal cell and squamous cell carcinoma utilizing frozen sections for real-time margin assessment while assessing 100% of the peripheral and deep margins, resulting in a recurrence rate of less than one percent. Real-time assessment in many tumor types is constrained by tissue size and complexity and the time to process tissue and evaluate slides while a patient is under general anesthesia. In this study, we developed an artificial intelligence (AI) platform, ArcticAI, which augments the surgical workflow to improve efficiency by reducing rate-limiting steps in tissue preprocessing and histological assessment through automated mapping and orientation of tumor to the surgical specimen. Using basal cell carcinoma (BCC) as a model system, the results demonstrate that ArcticAI can provide effective grossing recommendations, accurately identify tumor on histological sections, map tumor back onto the surgical resection map, and automate pathology report generation resulting in seamless communication between the surgical pathology laboratory and surgeon. AI-augmented-surgical excision workflows may make real-time margin assessment for the excision of more complex and challenging tumor types more accessible, leading to more streamlined and accurate tumor removal while increasing healthcare delivery efficiency.