Associations between Monocyte-to-High Density Lipoprotein Ratio and abdominal aortic calcification: Results of a nationwide survey

Abstract

AbstractBackgroundAbdominal aortic calcification (AAC), a critical marker for cardiovascular disease, is strongly correlated with metabolic disorders like diabetes and hypertension. Recent studies have highlighted the Monocyte-to-High Density Lipoprotein Ratio (MHR) as a potential biomarker for assessing the risk of atherosclerosis and cardiovascular diseases.Methods and ResultsThis cross-sectional study utilized data from the National Health and Nutrition Examination Surveys (NHANES) 2013-2014, focusing on U.S. adults aged 40 years and above. A total of 3017 participants were included, with AAC evaluated using dual-energy X-ray absorptiometry (DXA) scans, and the severity of AAC quantified based on the Kauppila score system. MHR was investigated for its association with AAC severity, employing multiple linear and multivariable logistic regression models to explore the relationship dynamics. After adjusting for potential confounders, including age, sex, race, socioeconomic factors, and other health-related variables, the analysis revealed a significant association between higher MHR levels and increased AAC scores. Participants with elevated MHR exhibited a greater prevalence and severity of AAC.ConclusionsThe study demonstrates a significant association between elevated MHR and the prevalence and severity of AAC, suggesting the utility of MHR as a predictive biomarker for cardiovascular risk assessment. These findings advocate for the inclusion of MHR in cardiovascular disease management and risk stratification protocols.