Author:
Halme Alex L. E.,Laakkonen Sanna,Rutanen Jarno,Nevalainen Olli P. O.,Sinisalo Marjatta,Horstia Saana,Mustonen Jussi M. J.,Pourjamal Negar,Vanhanen Aija,Investigators Solidarity Finland,Rosberg Tuomas,Renner Andreas,Perola Markus,Paukkeri Erja-Leena,Patovirta Riitta-Liisa,Parkkila Seppo,Paajanen Juuso,Nykänen Taina,Mäntylä Jarkko,Myllärniemi Marjukka,Mattila Tiina,Leinonen Maarit,Külmäsu Alvar,Kuutti Pauliina,Kuitunen Ilari,Kreivi Hanna-Riikka,Kilpeläinen Tuomas P.,Kauma Heikki,Kalliala Ilkka E. J.,Järvinen Petrus,Hankkio Riina,Hammarén Taina,Feuth Thijs,Ansakorpi Hanna,Ala-Karvia Riikka,Guyatt Gordon H.,Tikkinen Kari A. O.
Abstract
AbstractWe report the short- and long-term results of the SOLIDARITY Finland on mortality and other patient-important outcomes in patients hospitalised for COVID-19. Between 08/2021 and 03/2023, we randomised 156 patients in 15 hospitals. In the imatinib group, 7.2% of patients had died at 30 days and 13.3% at 1 year and in the standard of care group 4.1% and 8.3% (adjusted HR at 30 days 1.09, 95% CI 0.23–5.07). In a meta-analysis of randomised trials of imatinib versus standard of care (n=732), allocation to imatinib was associated with a mortality risk ratio of 0.73 (95% CI 0.32–1.63). At 1-year, self-reported recovery occurred in 79.0% in imatinib and in 88.3% in standard of care (RR 0.91, 95% CI 0.78-1.06). Of the 21 potential long COVID symptoms, patients often reported moderate or major bother from fatigue (24%), sleeping problems (19%) and memory difficulties (17%). We found no convincing difference between imatinib and standard of care groups in quality of life or symptom outcomes. The evidence raises serious doubts regarding the benefit of imatinib in reducing mortality, improving recovery, and preventing potential long COVID symptoms when given to patients hospitalised for COVID-19.
Publisher
Cold Spring Harbor Laboratory