Author:
Stewart Nicholas B.,Ahmed-Braimah Yasir H.,Cerne Daniel G.,McAllister Bryant F.
Abstract
AbstractA vast diversity of karyotypes exists within and between species, yet the mechanisms that shape this diversity are poorly understood. Here we investigate the role of biased meiotic segregation—i.e., meiotic drive—in karyotype evolution. The closely related species, Drosophila americana and D. novamexicana, provide an ideal system to investigate mechanisms of karyotypic diversification. Since their recent divergence, D. americana has evolved two centromeric fusions: one between the 2nd and 3rd chromosomes, and another between the X and 4th chromosomes. The 2-3 fusion is fixed in D. americana, but the X-4 fusion is polymorphic and varies in frequency along a latitudinal cline. Here we evaluate the hypothesis that these derived metacentric chromosomes segregate preferentially to the egg nucleus during female meiosis in D. americana. Using two different methods, we show that the fused X-4 chromosome is transmitted at an average frequency of ~57%, exceeding expectations of 50:50 Mendelian segregation. Three paracentric inversions are found in the vicinity of the X-4 fusion and could potentially influence chromosome segregation. Using crosses between lines with differing inversion arrangements, we show that the transmission bias persists regardless of inversion status. Transmission rates are also biased in D. americana/D. novamexicana hybrid females, favoring both the X-4 and 2-3 fused arrangements over their unfused homologs. Our results show that meiotic drive influences chromosome segregation in D. americana favoring derived arrangements in its reorganized karyotype. Moreover, the fused centromeres are the facilitators of biased segregation rather than associated chromosomal inversions.
Publisher
Cold Spring Harbor Laboratory
Reference37 articles.
1. Rapid evolution of assortative fertilization between recently allopatric species of Drosophila;International Journal of Evolutionary Biology,2012
2. Rates of karyotype evolution in placental mammals;Hereditas,1980
3. The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions
4. Meiotic drive of chromosomal knobs reshaped the maize genome;Genetics,1999
5. The selective elimination of inversion dicentric chromatids during meiosis in the eggs of Sciara impatiens;Genetics,1946
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献