Disruption of the coordination between host circadian rhythms and malaria parasite development alters the duration of the intraerythrocytic cycle

Author:

Subudhi Amit K.ORCID,O’Donnell Aidan J.ORCID,Ramaprasad AbhinayORCID,Abkallo Hussein M.ORCID,Kaushik AbhinavORCID,Ansari Hifzur R.ORCID,Abdel-Haleem Alyaa MORCID,Rached Fathia BenORCID,Kaneko OsamuORCID,Culleton RichardORCID,Reece Sarah E.ORCID,Pain ArnabORCID

Abstract

Malaria parasites complete their intra-erythrocytic developmental cycle (IDC) in multiples of 24 hours (depending on the species), suggesting a circadian basis to the asexual cell cycle, but the mechanism controlling this periodicity is unknown. Combining in vivo and in vitro approaches using rodent and human malaria parasites, we reveal that: (i) 57% of Plasmodium chabaudi genes exhibit 24 h “circadian” periodicity in transcription; (ii) 58% of these genes lose transcriptional rhythmicity when the IDC is out-of-synchrony with host rhythms; (iii) 9% of Plasmodium falciparum genes show circadian transcription under free-running conditions; (iv) Serpentine receptor 10 (SR10) has a circadian transcription profile and disrupting it in rodent malaria parasites shortens the IDC by 2-3 hours; (v) Multiple processes including DNA replication and the ubiquitin and proteasome pathways are affected by loss of coordination with host rhythms and by disruption of SR10. Our results show that malaria parasites are at least partly responsible for scheduling their IDCs explaining the fitness benefits of coordination with host rhythms.

Publisher

Cold Spring Harbor Laboratory

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. The Complex Interplay of Parasites, Their Hosts, and Circadian Clocks;Frontiers in Cellular and Infection Microbiology;2019-12-12

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