Reduced dimension stimulus decoding and column-based modeling reveal architectural differences of primary somatosensory finger maps between younger and older adults

Abstract

AbstractThe primary somatosensory cortex (SI) contains fine-grained tactile representations of the body, arranged in an orderly fashion. Using ultra-high resolution fMRI data to describe such detailed individual topographic maps or to detect group differences is challenging, because group alignment often does not preserve the high spatial detail of the data. Here, we use shared response modeling (SRM), a technique that allows group analyses by mapping individual stimulus-driven responses to a lower dimensional shared feature space, to detect age-related differences in sensory representations between younger and older adults using 7T-fMRI data. Using this method, we show that finger representations are more precise in Brodmann-Area (BA) 3b and BA1 compared to BA2 and motor areas, and that this hierarchical processing is preserved across age groups. By combining SRM with column-based decoding (C-SRM), we further show that the number of columns that optimally describes finger maps in SI is higher in younger compared to older adults in BA1, indicating a greater columnar size in older adults’ SI. Taken together, we conclude that SRM is suitable for finding fine-grained group differences in SI fMRI data at ultra-high-resolution, and we provide first evidence that the columnar architecture of a functional area changes with increasing age.