Immunological parameters ofProteus mirabilisisolates in Rheumatoid Arthritis patients with urinary tract infections

Abstract

AbstractRheumatoid arthritis (RA) is a chronic disease associated with many factors, such as urinary tract infection (UTI), and the complicated type of UTI bacteria isProteus mirabilis. Accordingly, 67 RA patients with UTI and 45 healthy controls from Baghdad regions were included in this study.Proteus mirabilisisolates were obtained from the urine of patients with RA and identified in 11.9% by biochemical tests and 16sRNA gene sequencing. ABO blood types, serum TNF-α level, serum rheumatoid factor (RF), C-reactive protein, and anti-bacterial antibody level of RA patients were compared to healthy controls. The study indicated that there is a correlation between blood type O, serum TNF-α level, rheumatoid factor (RF), C-reactive protein, and anti-bacterial antibody level of RA patients. The significant result was the increased serum level of TNF-α of RA patients who were infected with urease-produced bacteria, this might be due to the enzyme structure’s role in evoking the disease.