MaGplotR: a software for the analysis and visualization of multiple MaGeCK screen datasets through aggregation

Abstract

ABSTRACTMotivationMaGplotR analyzes multiple CRISPR screen datasets, identifies common hits, couples the hits to enrichment analysis and cluster plots, and produces publication-level plots. Output plots give information on the quality control of the screen data (e.g., sgRNA distribution) and show the best hits by aggregation from multiple screen experiments. To maximize comparability, rank is used to identify common hits. MaGplotR can also be used to analyze experiments where a control condition is used for multiple treatment conditions. MaGplotR is easy to use, with even just one argument.Availability and implementationMaGplotR is open-source code under MIT license. It is available athttps://github.com/alematia/MaGplotR.Contactalejandro.matia@inia.csic.es