Author:
d'Adda di Fagagna Fabrizio,Teo Soo-Hwang,Jackson Stephen P.
Abstract
In response to DNA
damage, cells engage a complex set of events that together comprise the
DNA-damage response (DDR). These events bring about the repair of the
damage and also slow down or halt cell cycle progression until the
damage has been removed. In stark contrast, the ends of linear
chromosomes, telomeres, are generally not perceived as DNA damage by the
cell even though they terminate the DNA double-helix. Nevertheless, it
has become clear over the past few years that many proteins involved in
the DDR, particularly those involved in responding to DNA double-strand
breaks, also play key roles in telomere maintenance. In this review, we
discuss the current knowledge of both the telomere and the DDR, and then
propose an integrated model for the events associated with the
metabolism of DNA ends in these two distinct physiological contexts.
Publisher
Cold Spring Harbor Laboratory
Subject
Developmental Biology,Genetics
Cited by
235 articles.
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