Author:
Zuo Fanglei,Sun Rui,Abolhassani Hassan,Du Likun,Wang Yating,Vlachiotis Stelios,Bertoglio Federico,Schubert Maren,Rezaei Nima,Chavoshzadeh Zahra,Guerra Concetta,Cavalli Andrea,Andréll Juni,Kumagai-Braesch Makiko,Xue Yintong,Cao Yunlong,Hust Michael,Robbiani Davide F.,Xie Xiaoliang Sunney,Hammarström Lennart,Marcotte Harold,Pan-Hammarström Qiang
Abstract
AbstractThe emergence of highly immune-escape Omicron variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), such as BQ and XBB, has led to concerns about the efficacy of vaccines. Using lentivirus-based pseudovirus neutralizing assay, we showed that heterologous vaccination involving parental mRNA vaccine as a booster or second booster in individuals that received two or three doses of inactivated vaccines strongly augments the neutralizing activity against emerging Omicron subvariants, including BF.7, BQ.1.1, and XBB.1, by 4.3-to 219-folds. Therefore, a heterologous boosting strategy with mRNA-based vaccines should be considered in populations where inactivated vaccines were primarily used.
Publisher
Cold Spring Harbor Laboratory