Quantitative model of aging-related muscle degeneration: a Drosophila study

Author:

Chechenova Maria,Stratton Hannah,Kiani Kaveh,Gerberich Erik,Alekseyenko Alesia,Tamba Natasya,An SooBin,Castillo Lizzet,Czajkowski Emily,Talley Christina,Bryantsev AntonORCID

Abstract

ABSTRACTChanges in the composition and functionality of somatic muscles is a universal hallmark of aging that is displayed by a wide range of species. In humans, complications arising from muscle decline due to sarcopenia aggravate morbidity and mortality rates. The genetics of aging-related deterioration of muscle tissue is not well understood, which prompted us to characterize aging-related muscle degeneration inDrosophila melanogaster(fruit fly), a leading model organism in experimental genetics. Adult flies demonstrate spontaneous degeneration of muscle fibers in all types of somatic muscles, which correlates with functional, chronological, and populational aging. Morphological data imply that individual muscle fibers die by necrosis. Using quantitative analysis, we demonstrate that muscle degeneration in aging flies has a genetic component. Chronic neuronal overstimulation of muscles promotes fiber degeneration rates, suggesting a role for the nervous system in muscle aging. From the other hand, muscles decoupled from neuronal stimulation retain a basal level of spontaneous degeneration, suggesting the presence of intrinsic factors. Based on our characterization,Drosophilacan be adopted for systematic screening and validation of genetic factors linked to aging-related muscle loss.

Publisher

Cold Spring Harbor Laboratory

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