Abstract
AbstractSequence variation among antigenicvargenes enablesPlasmodium falciparummalaria parasites to evade host immunity. Using long sequence reads from haploid clones from a mutation accumulation experiment, we detectvardiversity inconsistent with simple chromosomal inheritance. We discover putatively circular DNA that is strongly enriched forvargenes, which exist in multiple alleles per locus separated by recombination and indel events. Extrachromosomal DNA likely contributes to rapid antigenic diversification inP. falciparum.
Publisher
Cold Spring Harbor Laboratory
Cited by
1 articles.
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