Author:
Barad Mark,Blouin Ashley M.,Cain Chris K.
Abstract
Having recently shown that extinction of conditioned fear depends on L-type
voltage-gated calcium channels (LVGCCs), we have been seeking other protocols
that require this unusual induction mechanism. We tested latent inhibition
(LI) of fear, because LI resembles extinction except that cue exposures
precede, rather than follow, cue-shock pairing. Systemic injections of two
LVGCC inhibitors, nifedipine and diltiazem, before pre-exposure blocked LI
completely with no evidence of state-dependent learning. The results indicate
that extinction and LI share a common molecular requirement and may support
the notion that LI, like extinction, is a form of inhibitory learning.
Publisher
Cold Spring Harbor Laboratory
Subject
Cellular and Molecular Neuroscience,Cognitive Neuroscience,Neuropsychology and Physiological Psychology
Cited by
20 articles.
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