‘Synergistic-cidal’ effect of amoxicillin conjugated silver nanoparticles againstEscherichia coli

Abstract

AbstractWe are reporting the synergistic effects of amoxicillin coated silver nanoparticles, and sodium cholate is used as the stabilizer. Following, the synthesis of AgNPs physicochemical characterization was carried out using UV spectroscopy, XRD, FTIR, FESEM, AFM and NC-AFM analysis. The confirmation of AgNPs was confirmed UV spectral peak at 426 nm, the morphology of the nanoparticles was found to be spherical, oval with an average size of 35.50 nm. The cytotoxic effect was carried out using MTT assay with IC50 of 50.78 µg/mL and the antibacterial effect was observed as zone of inhibition of 12 mm for E.coli. The drug release was determined as 69%, which contributes to the therapeutic efficacy of water soluble based nanoparticles/nanomedicines for biomedical applications.