Wrapping of Drug Assembly with Silica Layer and Confinement through Reversible Linkage with Copper(II) for Glutathione-responsive Nanocapsule-Reference-Cited by-同舟云学术

Wrapping of Drug Assembly with Silica Layer and Confinement through Reversible Linkage with Copper(II) for Glutathione-responsive Nanocapsule

Published:2023-10-05 Issue:12 Volume:52 Page:870-873
ISSN:0366-7022
Container-title:Chemistry Letters
language:en
Short-container-title:

Author:

Matsune Hideki¹,Yoshida Ryoya²,Ikemizu Ren¹,Shiomori Koichiro¹,Yamamoto Tsuyoshi²,Kishida Masahiro²

Affiliation:

1. Department of Applied Chemistry, Faculty of Engineering, University of Miyazaki, 1-1 Gakuen Kibanadai-Nishi, Miyazaki 889-2192 , Japan

2. Department of Chemical Engineering, Faculty of Engineering, Kyushu University, 744 Moto-oka, Fukuoka 819-0395 , Japan

Abstract

Abstract Colloidal nano-assemblies containing doxorubicin (DOX) are prepared for the first time by co-precipitation with gluconate. The spherical assembly is wrapped with a porous silica layer via sol-gel process, and confined in the formed cage by treatment with copper(II) ions (Cu2+). The reversible linking of DOX with Cu2+ is allowed to suppress the leakage of DOX, but quick release is turned on in response to glutathione (GSH). The synthesized stimulus-responsive nanocapsules are characterized, and examined in a release test with/without GSH and applied to living HeLa cells.

Publisher

Oxford University Press (OUP)

Subject

General Chemistry

Link

https://academic.oup.com/chemlett/article-pdf/52/12/870/56205657/cl.230322.pdf

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