Exploring Novel Synthetic Concepts and Strategies Using Mechanochemistry

Abstract

Abstract In the field of organic synthesis, a ball-milling synthetic technique has garnered significant attention in recent years as an eco-friendly and sustainable alternative to traditional solution-based methods. In addition to its environmental benefits, solid-state organic synthesis using mechanochemical protocols enables access to novel areas of chemical space that are unavailable by conventional solution-based reactions. In this context, we are interested in designing and developing new organic transformations based on the unique solid-state reaction environment and the use of mechanical forces in a ball mill. In this Account, we highlight our latest findings concerning the creation of novel synthetic concepts and strategies. These approaches harness the distinctive reaction environment of mechanochemistry, rather than merely transferring well-established reactions from solution-based protocols to mechanochemical conditions.