EVALUATION OF THE TOXICITY OF THE ETHANOLIC EXTRACTS OF THE LEAVES OF HEXALOBUS MONOPETALUS ON THE KIDNEYS AND THE LIVER OF WISTAR RATS

Author:

Souham Abderaman,Behanzin Justin,Melanie Ahokpe,Sezan Alphonse

Abstract

The overall objective of our study is to evaluate the toxicity of ethanolic extracts of Hexalobus monopetalus leaves on the liver and kidney functions of rats in its therapeutic use. Thus, an ethanolic extract of the leaves was made, then a phytochemical screening of this extract. On the one hand, acute toxicity was measured in a 14-day feeding trial in Wistar rats, and on the other hand, a histopathological study of the organs removed was performed. The phytochemical screens of the ethanolic extracts obtained showed the presence of several phytochemical groups with therapeutic activity. Acute toxicity was noted at 3000 and 5000mg / kg PC doses of rats. Histopathological study revealed hepatic pycnosis at a dose of 5000 mg / kg PC in rats. Finally, no renal damage was observed

Publisher

Granthaalayah Publications and Printers

Reference36 articles.

1. Achille Richard. Plante Et Botanique - Hexalobus Monopetalus (A. Rich.) Benth., In Engl. Monogr. Afr. Pfl. Vi. 56. 2002-2014,

2. Assogba Marc Napoléon. Quelques Enquêtes Sur La Pharmacopée Traditionnelle Vétérinaire En République Du Benin, 1984 -22 Pp18

3. Audrey Gilly., Plantes Et Médicaments, 20117p

4. Augustin De Candolle. Plante Et Botanique - Hexalobus, In Mem. Soc. Phys. Gerev. V. (1832)1985 212 (Mem. Anon. 36. T. 5 A).

5. Bourra Hicham, Toxicités Aigue Et Chronique: Notions De Base. Http ://Qualite-HygieneSecurite-Environnement.Over-Blog.Com(2008),

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3