METHOD DEVELOPMENT FOR SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND NATEGLINIDE IN COMBINED DOSAGE FORM BY UV SPECTROSCOPY.-Reference-Cited by-同舟云学术

METHOD DEVELOPMENT FOR SIMULTANEOUS ESTIMATION OF ATORVASTATIN AND NATEGLINIDE IN COMBINED DOSAGE FORM BY UV SPECTROSCOPY.

Published:2020 Issue:9 Volume:7 Page:16-21
ISSN:2349-5340
Container-title:Indian Journal of Medical Research and Pharmaceutical Sciences
language:en
Short-container-title:

Author:

Abstract

Keywords: Simultaneous estimation, combined dosage forms, Atorvastatin, Nateglinide. In the present work, the quantitative estimation of both the drugs in combined dosage forms was carried out. A new, simple, reliable, sensitive, rapid, and economical procedure for simultaneous estimation of atorvastatin calcium and nateglinide in a combined dosage form by UV spectroscopy using the simultaneous equation method was developed. Native ultraviolet absorbance maxima of the two chemotherapeutic agents were used. As both compounds do not interact chemically in methanol, the two wavelengths 246.15 nm for atorvastatin calcium and 206.6 nm for nateglinide were used. Both the drugs obeyed Beer's law in the concentration range (1-10 µg/ml) that was employed in this method. The method developed was validated to determine its linearity (r2=0.996 for atorvastatin and r2=0.997 for nateglinide), precision, reproducibility, and sensitivity. .

Publisher

Granthaalayah Publications and Printers

Subject

Polymers and Plastics

Reference9 articles.

1. Indian Pharmacopoeia. Vol. 2, 4th Ed. pp. 659 Governments of India, Ministry of Health and Family Welfare, 1996 India.

2. United States Pharmacopoeia 27, National Formulary 22. United States Rockville, MD. 20852, U.S.A Pharmacopoeial Convention Inc, 2004; (2) 1283-1284.

3. Beckett AK and Stanlake JB. Practical Pharmaceutical Chemistry. 4thedition, Part II, CBS Publishers, New Delhi. 1997; 286-288.

4. S. Jadhav, M. Bhatia, S. Thamke, A. Pishawikar, Spectrophotometric Methods for Estimation of Atorvastatin Calcium Form Tablet Dosage Forms International Journal of PharmTech Research , 2010;2(3):1948-1953.

5. V.P Godse., M.N. Deodhar, A.V. Bhosale, R.A. Sonawane., P.S. Sakpal, D.D. Borkar and Y.S. Bafana, Simultaneous Spectrophotometric Estimation of Ezetimibe and Atorvastatin in Pharmaceutical Dosage Form Asian J. Research Chem. 2009; 2(1):86-89.