STUDY OF BLOOD UREA NITROGEN (BUN), SERUM CREATININE IN DIABETIC AND NON-DIABETIC PATIENTS IN A TERTIARY CARE HOSPITAL

Abstract

Introduction: Patients of Diabetes mellitus type 2 are known to have high levels of BUN and Serum creatinine levels as compared to non-diabetics. There is an association between the raised BUN, serum creatinine levels and poor glycemic controls, subsequently leading to complications like nephropathy in Diabetic patients. Aim and objectives: The aim of this study is to assess the BUN, Serum creatinine levels in relation to fasting plasma glucose (FPG) and 2-hour post plasma glucose (2h-PG) status in diabetic patients as compared to non-diabetics. Materials and methods: 215 cases of Diabetes Mellitus were recruited along with the 100 age and sex matched controls who were healthy and non-diabetic and their blood samples were analyzed for BUN and FPG and 2-h-PG after 75-gram oral glucose in National Accreditation Board for testing and calibration Laboratories (NABL) certified laboratory. Results: In our study we have found that there is a significant association of FPG, 2h-PG, BUN and serum creatinine in diabetic cases as compared to non-diabetic controls. There also exists a significant positive correlation between mean BUN (12.3 ± 5.9mg/dL) and mean FPG (159.72 ± 71.60 mg/dL) and mean 2h-PG (222.76 ± 100.86 mg/dL) levels. Conclusion: BUN and serum creatinine are the markers in diabetes patients to assess the diabetic nephropathy. Serum BUN may be preferred over serum creatinine in assessing early renal impairment due to positive correlation with fasting and post prandial glycemic levels. Keywords: BUN, Nephropathy, FPG, 2h-PG, Diabetic complications.