Comparison of DNA Damage and Homocysteine Content in Blood of Thyroid Carcinoma Patients and Control Subjects in Punjab, Pakistan

Abstract

Background: Thyroid cancers are common endocrine tumors with diverse medical and histological structures. During development/progression from normal to neoplastic cell, there is a gradual increase in the function/activity of proto-oncogenes, transcription factors and metastasis elements. The main objective of this study is to evaluate per-oxidation of lipid content, total oxidative stress, and the profile of homocysteine (and DNA damage) in the erythrocytes of thyroid carcinoma patients as compared with those of control subjects. Methods: All risk variables and biochemical analyses were quantitatively determined using standard methods. Results: A noteworthy increase in malondialdehyde, globulin, and DNA damage in thyroid carcinoma patients were repeatedly observed. In contrast, healthy individuals showed an increased level of HDL-C and total anti-oxidant response. Conclusion: It is suggested that these parameters have a pivotal role in the diagnostic process of determining thyroid carcinoma patients. Oxidized products of macromolecules in the blood of such patients impart major function in causing thyroid carcinoma disease.