Hypocarnitinemia Observed in an Infant Treated with Short-Term Administration of Antibiotic Containing Pivalic Acid

Author:

Nakazaki Kimitaka1,Ogawa Erika1,Ishige Mika1,Ishige Nobuyuki2,Fuchigami Tatsuo1,Takahashi Shori1

Affiliation:

1. Department of Pediatrics and Child Health, Nihon University School of Medicine

2. Tokyo Health Service Association

Publisher

Tohoku University Medical Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference10 articles.

1. Abrahamsson, K., Eriksson, B.O., Holme, E., Jodal, U., Lindstedt, S. & Nordin, I. (1994) Impaired ketogenesis in carnitine depletion caused by short-term administration of pivalic acid prodrug. Biochem. Med. Metab. Biol., 52, 18-21.

2. Brass, E.P. (2002) Pivalate-generating prodrugs and carnitine homeostasis in man. Pharmacol. Rev., 54, 589-598.

3. Holme, E., Jodal, U., Linstedt, S. & Nordin, I. (1992) Effects of pivalic acid-containing prodrugs on carnitine homeostasis and on response to fasting in children. Scand. J. Clin. Lab. Invest., 52, 361-372.

4. Ito, M., Fukuda, M., Suzuki, Y., Wakamoto, H. & Ishii, E. (2017) Carnitine-related hypoglycemia caused by 3 days of pivalate antibiotic therapy in a patient with severe muscular dystrophy: a case report. BMC Pediatr., 17, 73.

5. Ito, T., Sugiyama, N., Kobayashi, M., Kidouchi, K., Itoh, T., Uemura, O., Sugiyama, K. & Togari, H. (1995) Alteration of ammonia and carnitine levels in short-term treatment with pivalic acids-containing prodrug. Tohoku J. Exp. Med., 175, 43-53.

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