Expression Levels of Eosinophil Granule Protein mRNAs in Induced Sputum Reflect Airway Hyperresponsiveness and Airflow Limitation

Author:

Jung Jae-Woo12,Kang Hye-Ryun13,Lee Hyun-Seung13,Park Heung-Woo13,Cho Sang Heon13,Min Kyung-Up13,Sohn Seong-Wook4

Affiliation:

1. Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center

2. Department of Internal Medicine, Chung-Ang University College of Medicine

3. Department of Internal Medicine, Seoul National University College of Medicine

4. Department of Internal Medicine, Dongguk University Ilsan Hospital

Publisher

Tohoku University Medical Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference29 articles.

1. Ackerman, S.J., Loegering, D.A., Venge, P., Olsson, I., Harley, J.B., Fauci, A.S. & Gleich, G.J. (1983) Distinctive cationic proteins of the human eosinophil granule: major basic protein, eosinophil cationic protein, and eosinophil-derived neurotoxin. J. Immunol., 131, 2977-2982.

2. Badar, A., Saeed, W., Hussain, M.M. & Aslam, M. (2004) Correlation of eosinophil cationic protein with severity of asthma. J. Ayub Med. Coll. Abbottabad, 16, 66-71.

3. Bartoli, M.L., Bacci, E., Carnevali, S., Cianchetti, S., Dente, F.L., Di Franco, A., Giannini, D., Taccola, M., Vagaggini, B. & Paggiaro, P.L. (2004) Clinical assessment of asthma severity partially corresponds to sputum eosinophilic airway inflammation. Respir. Med., 98, 184-193.

4. Berry, M.A., Parker, D., Neale, N., Woodman, L., Morgan, A., Monk, P., Bradding, P., Wardlaw, A.J., Pavord, I.D. & Brightling, C.E. (2004) Sputum and bronchial submucosal IL-13 expression in asthma and eosinophilic bronchitis. J. Allergy Clin. Immunol., 114, 1106-1109.

5. Brightling, C.E., Symon, F.A., Birring, S.S., Bradding, P., Wardlaw, A.J. & Pavord, I.D. (2003) Comparison of airway immunopathology of eosinophilic bronchitis and asthma. Thorax, 58, 528-532.

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