Reduction in Glutamine/Glutamate Levels in the Cerebral Cortex after Adrenocorticotropic Hormone Therapy in Patients with West Syndrome

Author:

Munakata Mitsutoshi1,Togashi Noriko2,Sakamoto Osamu1,Haginoya Kazuhiro3,Kobayashi Yasuko4,Onuma Akira3,Iinuma Kazuie1,Kure Shigeo1

Affiliation:

1. Department of Pediatrics, Tohoku University School of Medicine

2. Department of Neurology, Miyagi Children’s Hospital

3. Department of Pediatric Neurology, Takuto Rehabilitation Center for Children

4. Department of Pediatrics, Sendai Nishitaga National Hospital

Publisher

Tohoku University Medical Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference35 articles.

1. Ábrahám, I., Juhász, G., Kékesi, K.A. & Kovács, K.J. (1996) Effect of intrahippocampal dexamethasone on the levels of amino acid transmitters and neuronal excitability. Brain Res., 733, 56-63.

2. Baslow, M.H. (2003) Brain N-acetylaspartate as a molecular water pump and its role in the etiology of Canavan disease: a mechanistic explanation. J. Mol. Neurosci., 21, 185-190.

3. Brunson, K.L., Avishai-Eliner, S. & Baram, T.Z. (2002) ACTH treatment of infantile spasms: mechanisms of its effects in modulation of neuronal excitability. Int. Rev. Neurobiol., 49, 185-197.

4. Castillo, M., Kwock, L. & Mukherji, S.K. (1996) Clinical applications of proton MR spectroscopy. AJNR Am. J. Neuroradiol., 17, 1-15.

5. Douglas, R. & Martin, K. (1998) Neocortex. In The synaptic organization of the brain, 4th ed., edited by Shepherd, G.M. Oxford University Press, New York, pp. 459-509.

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