Oxidative Stress Impairs the Stimulatory Effect of S100 Proteins on Protein Phosphatase 5 Activity

Author:

Yamaguchi Fuminori1,Tsuchiya Mitsumasa2,Shimamoto Seiko3,Fujimoto Tomohito2,Tokumitsu Hiroshi2,Tokuda Masaaki1,Kobayashi Ryoji2

Affiliation:

1. Department of Cell Physiology, Faculty of Medicine, Kagawa University

2. Department of Signal Transduction Sciences, Faculty of Medicine, Kagawa University

3. Laboratory of Oncology, Institute of Microbial Chemistry, Microbial Chemistry Research Foundation

Publisher

Tohoku University Medical Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference48 articles.

1. Arcuri, C., Bianchi, R., Brozzi, F. & Donato, R. (2005) S100B increases proliferation in PC12 neuronal cells and reduces their responsiveness to nerve growth factor via Akt activation. J. Biol. Chem., 280, 4402-4414.

2. Becker, W., Kentrup, H., Klumpp, S., Schultz, J.E. & Joost, H.G. (1994) Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain. J. Biol. Chem., 269, 22586-22592.

3. Bulk, E., Sargin, B., Krug, U., Hascher, A., Jun, Y., Knop, M., Kerkhoff, C., Gerke, V., Liersch, R., Mesters, R.M., Hotfilder, M., Marra, A., Koschmieder, S., Dugas, M., Berdel, W.E., et al. (2009) S100A2 induces metastasis in non-small cell lung cancer. Clin. Cancer Res., 15, 22-29.

4. Chen, M.X., McPartlin, A.E., Brown, L., Chen, Y.H., Barker, H.M. & Cohen, P.T. (1994) A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus. EMBO J., 13, 4278-4290.

5. Chen, X., Liu, X., Lang, H., Zhang, S., Luo, Y. & Zhang, J. (2015) S100 calcium-binding protein A6 promotes epithelial-mesenchymal transition through beta-catenin in pancreatic cancer cell line. PLoS One, 10, e0121319.

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