Genetic Polymorphisms in APC, DVL2, and AXIN1 Are Associated with Susceptibility, Advanced TNM Stage or Tumor Location in Colorectal Cancer

Author:

Rosales-Reynoso Mónica Alejandra1,Saucedo-Sariñana Anilú Margarita1,Contreras-Díaz Karla Berenice1,Márquez-González Rosa María1,Barros-Núñez Patricio2,Pineda-Razo Tomás Daniel3,Marin-Contreras María Eugenia4,Durán-Anguiano Óscar5,Gallegos-Arreola Martha Patricia6,Flores-Martínez Silvia Esperanza1,Sánchez-Corona José1

Affiliation:

1. Molecular Medicine Division, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS)

2. Research Unit of Metabolic Diseases, Pediatric UMAE, Instituto Mexicano del Seguro Social (IMSS)

3. Medical Oncology Service, Specialty Hospital, Instituto Mexicano del Seguro Social (IMSS)

4. Gastroenterology Service, Specialty Hospital, Instituto Mexicano del Seguro Social (IMSS)

5. Coloproctology Service, Specialty Hospital, Instituto Mexicano del Seguro Social (IMSS)

6. Genetic Division, Centro de Investigación Biomédica de Occidente (CIBO), Instituto Mexicano del Seguro Social (IMSS)

Publisher

Tohoku University Medical Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference43 articles.

1. Brandstedt, J., Wangefjord, S., Borgquist, S., Nodin, B., Eberhard, J., Manjer, J. & Jirstrom, K. (2013) Influence of anthropometric factors on tumour biological characteristics of colorectal cancer in men and women: a cohort study. J. Transl. Med., 11, 293.

2. Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A. & Jemal, A. (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin., 68, 394-424.

3. Colussi, D., Brandi, G., Bazzoli, F. & Ricciardiello, L. (2013) Molecular pathways involved in colorectal cancer: implications for disease behavior and prevention. Int. J. Mol. Sci., 14, 16365-16385.

4. Evertsson, S., Lindblom, A. & Sun, X.F. (2001) APC I1307K and E1317Q variants are rare or do not occur in Swedish colorectal cancer patients. Eur. J. Cancer, 37, 499-502.

5. Feng, M., Fang, X., Yang, Q., Ouyang, G., Chen, D., Ma, X., Li, H. & Xie, W. (2014) Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer. Oncol. Lett., 8, 139-144.

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