Morphological and Morphometrical Analyses of Fracture-Healing Sites of an Atypical Femoral Fracture in Patients with and without Long-Term Bisphosphonate Treatment for Osteoporosis: A Report of Two Cases

Author:

Aki Takashi1,Hashimoto Ko1,Uozumi Hiroaki2,Saito Masahiro3,Sugawara Ko4,Suzuki Manabu1,Hamada Soshi1,Ito Akemi5,Itoi Eiji1

Affiliation:

1. Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine

2. Omagari Orthopaedic Clinic

3. Department of Pathology, Hiraka General Hospital

4. Sugawara Orthopaedic Clinic

5. Ito Bone Histomorphometry Institute

Publisher

Tohoku University Medical Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference26 articles.

1. Adami, S., Libanati, C., Boonen, S., Cummings, S.R., Ho, P.R., Wang, A., Siris, E., Lane, J., Group, F.F.-H.W., Adachi, J.D., Bhandari, M., de Gregorio, L., Gilchrist, N., Lyritis, G., Moller, G., et al. (2012) Denosumab treatment in postmenopausal women with osteoporosis does not interfere with fracture-healing: results from the FREEDOM trial. J. Bone Joint Surg. Am., 94, 2113-2119.

2. Bernhard, A., Milovanovic, P., Zimmermann, E.A., Hahn, M., Djonic, D., Krause, M., Breer, S., Puschel, K., Djuric, M., Amling, M. & Busse, B. (2013) Micro-morphological properties of osteons reveal changes in cortical bone stability during aging, osteoporosis, and bisphosphonate treatment in women. Osteoporos. Int., 24, 2671-2680.

3. Bone, H.G., Hosking, D., Devogelaer, J.P., Tucci, J.R., Emkey, R.D., Tonino, R.P., Rodriguez-Portales, J.A., Downs, R.W., Gupta, J., Santora, A.C., Liberman, U.A. & Alendronate Phase, I.I.I.O.T.S.G. (2004) Ten years’ experience with alendronate for osteoporosis in postmenopausal women. N. Engl. J. Med., 350, 1189-1199.

4. Edwards, B.J., Bunta, A.D., Lane, J., Odvina, C., Rao, D.S., Raisch, D.W., McKoy, J.M., Omar, I., Belknap, S.M., Garg, V., Hahr, A.J., Samaras, A.T., Fisher, M.J., West, D.P., Langman, C.B., et al. (2013) Bisphosphonates and nonhealing femoral fractures: analysis of the FDA Adverse Event Reporting System (FAERS) and international safety efforts: a systematic review from the Research on Adverse Drug Events And Reports (RADAR) project. J. Bone Joint Surg. Am., 95, 297-307.

5. Egol, K.A., Park, J.H., Rosenberg, Z.S., Peck, V. & Tejwani, N.C. (2014) Healing delayed but generally reliable after bisphosphonate-associated complete femur fractures treated with IM nails. Clin. Orthop. Relat. Res., 472, 2728-2734.

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