Nitric Oxide Synthase Modulates the Antihyperalgesic Effect of the NMDA Receptor Antagonist MK-801 on Carrageenan-Induced Inflammatory Pain in Rats

Author:

Srebro Dragana P.1,Vucković Sonja M.1,Savic Vujovic Katarina R.1,Prostran Milica S.1

Affiliation:

1. Department of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade

Publisher

Tohoku University Medical Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference54 articles.

1. Andreasen, J.T., Bach, A., Gynther, M., Nasser, A., Mogensen, J., Strømgaard, K. & Pickering, D.S. (2013) UCCB01-125, a dimeric inhibitor of PSD-95, reduces inflammatory pain without disrupting cognitive or motor performance: comparison with the NMDA receptor antagonist MK-801. Neuropharmacology, 67, 193-200.

2. Begon, S., Pickering, G., Eschalier, A. & Dubray, C. (2000) Magnesium and MK-801 have a similar effect in two experimental models of neuropathic pain. Brain Res., 887, 436-439.

3. Berrino, L., Oliva, P., Massimo, F., Aurilio, C., Maione, S., Grella, A. & Rossi, F. (2003) Antinociceptive effect in mice of intraperitoneal N-methyl-D-aspartate receptor antagonists in the formalin test. Eur. J. Pain, 7, 131-137.

4. Boettger, M.K., Uceyler, N., Zelenka, M., Schmitt, A., Reif, A., Chen, Y. & Sommer, C. (2007) Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice. Eur. J. Pain, 11, 810-818.

5. Boyce, S., Wyatt, A., Webb, J.K., O’Donnell, R., Mason, G., Rigby, M., Sirinathsinghji, D., Hill, R.G. & Rupniak, N.M. (1999) Selective NMDA NR2B antagonists induce antinociception without motor dysfunction: correlation with restricted localisation of NR2B subunit in dorsal horn. Neuropharmacology, 38, 611-623.

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