A Synthetic Serine Protease Inhibitor, Nafamostat Mesilate, Is a Drug Potentially Applicable to the Treatment of Ebola Virus Disease

Author:

Nishimura Hidekazu1,Yamaya Mutsuo2

Affiliation:

1. Virus Research Center, Clinical Research Division, Sendai Medical Center

2. Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University Graduate School of Medicine

Publisher

Tohoku University Medical Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference30 articles.

1. Aoyama, T., Ino, Y., Ozeki, M., Oda, M., Sato, T., Koshiyama, Y., Suzuki, S. & Fujita, M. (1984) Pharmacological studies of FUT-175, nafamstat mesilate. I. Inhibition of protease activity in in vitro and in vivo experiments. Jpn. J. Pharmacol., 35, 203-227.

2. Bray, M., Hatfill, S., Hensley, L. & Huggins, J.W. (2001) Haematological, biochemical and coagulation changes in mice, guinea-pigs and monkeys infected with a mouse-adapted variant of Ebola Zaire virus. J. Comp. Pathol., 125, 243-253.

3. Centers for Disease Control and Prevention (2015) Ebola virus disease (EVD) information for clinicians in U.S. healthcare settings. http://www.cdc.gov/vhf/ebola/hcp/clinician-information-us-healthcare-settings.html [Accessed: January 30, 2015].

4. Chandran, K., Sullivan, N.J., Felbor, U., Whelan, S.P. & Cunningham, J.M. (2005) Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science, 308, 1643-1645.

5. Feldmann, H., Sanchez, A. & Geisbert, T.W. (2013) Filoviridae: Marburg and Ebola viruses. Chapter 32. In Fields Virology, 6th ed., edited by Knipe, D.M. & Howley, P.M. Lippincott Williams & Wilkins, Philadelphia, PA, pp. 923-956.

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