Serum Soluble Interleukin-2 Receptor Is a Biomarker for Pneumocystis jirovecii Pneumonia among Patients with Rheumatoid Arthritis under Methotrexate Therapy

Author:

Sakamoto Noriho1,Hara Shintaro12,Ishimoto Hiroshi1,Nakashima Shota1,Yura Hirokazu1,Miyamura Takuto1,Okuno Daisuke1,Hara Atsuko1,Kakugawa Tomoyuki1,Yamaguchi Hiroyuki1,Obase Yasushi1,Kushima Hisako3,Ishii Hiroshi3,Noguchi Shingo4,Kido Takashi4,Kobayashi Tsutomu5,Soejima Yoshifumi5,Yoshioka Sumako6,Ishimatsu Yuji7,Yatera Kazuhiro4,Kadota Jun-ichi8,Mukae Hiroshi1

Affiliation:

1. Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences

2. Department of Respiratory Medicine, Aino Memorial Hospital

3. Department of Respiratory Medicine, Fukuoka University Hospital

4. Department of Respiratory Medicine, School of Medicine, University of Occupational and Environmental Health, Japan

5. Department of Respiratory Medicine, Sasebo Chuo Hospital

6. Department of Respiratory Medicine, Nagasaki Harbor Medical Center

7. Department of Nursing, Nagasaki University Graduate School of Biomedical Sciences

8. Department of Respiratory Medicine and Infectious Diseases, Oita University Faculty of Medicine

Publisher

Tohoku University Medical Press

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference40 articles.

1. Alanio, A. & Bretagne, S. (2017) Pneumocystis jirovecii detection in asymptomatic patients: what does its natural history tell us? F1000Res., 6, 739.

2. Aletaha, D., Neogi, T., Silman, A.J., Funovits, J., Felson, D.T., Bingham, C.O. 3rd, Birnbaum, N.S., Burmester, G.R., Bykerk, V.P., Cohen, M.D., Combe, B., Costenbader, K.H., Dougados, M., Emery, P., Ferraccioli, G., et al. (2010) 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum., 62, 2569-2581.

3. Chan, E.S. & Cronstein, B.N. (2002) Molecular action of methotrexate in inflammatory diseases. Arthritis Res., 4, 266-273.

4. Chodorowska, G., Czelej, D. & Niewiedziol, M. (2003) Interleukin-2 and its soluble receptor in selected drug-induced cutaneous reactions. Ann. Univ. Mariae Curie Sklodowska Med., 58, 7-13.

5. Genestier, L., Paillot, R., Fournel, S., Ferraro, C., Miossec, P. & Revillard, J.P. (1998) Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells. J. Clin. Invest., 102, 322-328.

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